Dynamics of ketone body metabolism in diabetic rats
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Ketone-body metabolism in tumour-bearing rats.
During starvation for 72 h, tumour-bearing rats showed accelerated ketonaemia and marked ketonuria. Total blood [ketone bodies] were 8.53 mM and 3.34 mM in tumour-bearing and control (non-tumour-bearing) rats respectively (P less than 0.001). The [3-hydroxybutyrate]/[acetoacetate] ratio was 1.3 in the tumour-bearing rats, compared with 3.2 in the controls at 72 h (P less than 0.001). Blood [glu...
متن کاملGlutamine and ketone-body metabolism in the gut of streptozotocin-diabetic rats.
1. In short- and long-term diabetic rats there is a marked increase in size of both the small intestine and colon, which was accompanied by marked decreases (P less than 0.001) and increases (P less than 0.001) in the arterial concentrations of glutamine and ketone bodies respectively. 2. Portal-drained viscera blood flow increased by approx. 14-37% when expressed as ml/100 g body wt., but was ...
متن کاملRecent developments in ketone-body metabolism.
There is now no doubt that ketone bodies (acetoacetate and D-3-hydroxybutyrate) are important oxidizable substrates for peripheral tissues, especially the brain. Although oxidation is the major fate of ketone bodies, more recent evidence suggests that ketone bodies can act as lipogenic substrates in certain tissues, notably the developing brain and the lactating mammary gland. Apart from their ...
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Garber, A. J., Menzel, P. H., Boden, G. & Owen, 0. E. (1974) J. Clin. Invest. 54,981-989 Long, C . L., Spencer, J. L., Kinney, J. M. & Geiger, J. W. (1971) J. Awl. Physiol. 31.102-109 Owen, 0. E., Reichard, G. A., Jr., Boden, G., Patel, M. S. & Trapp, V. E. (1978) in Advances in Modern Nutrition: Diabetes, Obesity and Vascular Disease (Katzen, H. M . & Mahler, R. J., eds.), vol. 2, pp. 517-550,...
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Ketone bodies are metabolized through evolutionarily conserved pathways that support bioenergetic homeostasis, particularly in brain, heart, and skeletal muscle when carbohydrates are in short supply. The metabolism of ketone bodies interfaces with the tricarboxylic acid cycle, β-oxidation of fatty acids, de novo lipogenesis, sterol biosynthesis, glucose metabolism, the mitochondrial electron t...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1972
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf01212264